Boron, trifluoro(methanol)-, (T-4)- → HCID 13362028、化合物

HRID 980950ノート

反応式

HRID 980950 の反応式
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH:9]1[C:17]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25]O.B(F)(F)F>>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH3:25])=[O:15])[CH:9]1[C:17]1[C:18]([Cl:24])=[CH:19][CH:20]=[CH:21][C:22]=1[Cl:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 13361993HCID 13361993、化合物

生成物 1

HCID 13362028HCID 13362028、化合物

実験手順

A solution of 25 g of 1-benzyl-2-(2,6-dichlorophenyl)-5-oxopyrrolidin-3-carboxylic acid in 247 ml of boron trifluoride methanol was refluxed for 7 hours and then concentrated in vacuo to a solid. The solid was dissolved in chloroform and the chloroform washed with a saturated sodium carbonate solution and then with a saturated sodium bicarbonate solution. Drying (Na2SO4), filtration, and concentration in vacuo provided 18 g of off-white crystals, m.p. 97°-102°.

後処理

  1. concentrationconcentrated in vacuo to a solid
  2. dissolutionThe solid was dissolved in chloroform
  3. washthe chloroform washed with a saturated sodium carbonate solution
  4. customDrying
  5. filtration(Na2SO4), filtration, and concentration in vacuo

出典と根拠

ORDレコード
ord-016d9b9d53474b8a85585a44b69d3841
出典データセット
uspto-grants-1987_01
特許番号
US04639529

反応ノート

読み込み中…