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Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,2-Dimethoxy-1-methylethylamine | HCID 93658 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(1,1-dimethoxyprop-2-yl)urethane | HCID 15069987 | — |
反応手順
80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K CO2. The solution is concentrated and the residue is distilled.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04990517 |
| 出典データセット | uspto-grants-1991_02 |
| ORD ID | ord-601fee977f964477af88a7844b7489f2 |
| 出典メモ | uspto-grants-1991_02 |