Ethanol → Benzoic acid, 2,4-dichloro-5-fluoro-, ethyl ester
反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:13]([OH:15])[CH3:14]>>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([O:15][CH2:13][CH3:14])=[O:5]参加物
3
実験手順
84 g of 2,4-dichloro-5-fluoro-benzoyl chloride are added dropwise to 250 ml of anhydrous ethanol at 50° to 60° C., the temperature being maintained by occasional cooling with ice-water. The mixture is then refluxed for about a further hour, the excess alcohol is distilled off and the residue is fractionated in vacuo. 84.9 g (~97%) of ethyl 2,4-dichloro-5-fluoro-benzoate are obtained at 132°-135° C./8 mbar.
後処理
- temperaturethe temperature being maintained
- temperatureThe mixture is then refluxed for about a further hour
- distillationthe excess alcohol is distilled off
出典と根拠
- ORDレコード
- ord-84f4a811032d4a7ea1669fb806d713ad
- 出典データセット
- uspto-grants-1991_02
- 特許番号
- US04990646
反応ノート
読み込み中…