Water → 3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid

HRID 981615ノート

反応式

HRID 981615 の反応式
[OH-].[K+].O.[C:4]1([CH2:10][O:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])[CH2:16][CH2:15]2)=[O:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[C:4]1([CH2:10][O:11][C:12]([N:14]2[CH2:15][CH2:16][CH:17]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:19]2)=[O:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 14989191Benzyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

生成物 1

HCID 98953153-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred and cooled (15° C.) mixture of 11.1 parts of potassium hydroxide and 96 parts of water was added dropwise a solution of 31.8 parts of ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate in 38 parts of ethanol during 20 minutes. Upon complete addition, stirring was continued overnight at room temperature. The reaction mixture was evaporated at <50° C. The reaction mixture was poured into crushed ice and treated with concentrated hydrochloric acid. The separated aqueous layer was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 29 parts (100%) of 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid as a residue (int. 33).

後処理

  1. temperaturecooled
  2. additionUpon complete addition
  3. stirringstirring
  4. customThe reaction mixture was evaporated at <50° C
  5. additionThe reaction mixture was poured
  6. custominto crushed ice
  7. additiontreated with concentrated hydrochloric acid
  8. extractionThe separated aqueous layer was extracted with dichloromethane
  9. customThe extract was dried
  10. filtrationfiltered
  11. customevaporated

出典と根拠

ORDレコード
ord-b7f53fc2571149ce864bd56a2db2390b
出典データセット
uspto-grants-1991_02
特許番号
US04992433

反応ノート

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