Dichloromethane → HCID 67926768、化合物

HRID 981766ノート

反応式

HRID 981766 の反応式
[CH3:1][O:2][C:3](=[O:10])[CH:4]([CH2:6][C:7]([OH:9])=[O:8])[OH:5].C(OC(=NC(C)C)NC(C)C)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH2:28](Cl)Cl>CN(C=O)C>[CH3:28][O:8][C:7](=[O:9])[CH2:6][CH:4]([OH:5])[C:3]([O:2][CH2:1][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:10]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 11128254o-Benzyl-n,n'-diisopropylisoureaHCID 121005551-Methyl malate

生成物 1

HCID 67926768HCID 67926768、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Malic acid monomethyl ester (Example 2A) was dissolved in DMF and one equivalent of O-benzyl-N,N'-diisopropylisourea was added. The reaction mixture was stirred at room temperature for about 17 hours. Methylene chloride was added to the mixture and the suspension was filtered to remove the diisopropylurea. The filtrate was further diluted with methylene chloride and washed with water, 10% aqueous sodium carbonate, water, and with brine and was dried over magnesium sulfate. After filtration and evaporation the monobenzyl monomethyl ester was obtained as an oil.

後処理

  1. filtrationthe suspension was filtered
  2. customto remove the diisopropylurea
  3. additionThe filtrate was further diluted with methylene chloride
  4. washwashed with water, 10% aqueous sodium carbonate, water
  5. dry with materialwith brine and was dried over magnesium sulfate
  6. filtrationAfter filtration and evaporation the monobenzyl monomethyl ester
  7. customwas obtained as an oil

出典と根拠

ORDレコード
ord-4386ffe2627e4225bdb58f6ef0a8da7e
出典データセット
uspto-grants-1991_02
特許番号
US04992544

反応ノート

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