Hydrochloric Acid → 1-Aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride

HRID 982094ノート

反応式

HRID 982094 の反応式
C(O)=O.[NH2:4][CH2:5][C:6]1[C:15]2[C:10](=[C:11]([OH:16])[CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=1.NCC1C2[C:29](=[C:30]([OH:35])C=CC=2)CC(C2C=CC=CC=2)C=1.[ClH:42]>C(OC(=O)C)(=O)C>[ClH:42].[NH2:4][CH2:5][C:6]1[C:15]2[C:10](=[C:11]([O:16][C:30](=[O:35])[CH3:29])[CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 200690411-Aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthaleneHCID 200690431-Aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthalene formic acid salt

生成物 1

HCID 200690701-Aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

A suspension of 1-aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthalene formic acid salt, the product of Example 2, in acetic anhydride saturated with anhydrous hydrogen chloride is stirred at ambient temperature for 48 h. A solid is collected by filtration and washed with diethyl ether. Crystallization of the crude material is achieved by dissolving the powder in hot ethanol, adding water, filtering the solution hot and allowing it to cool. Filtration and drying of the solid collected affords 1-aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride.

後処理

  1. filtrationA solid is collected by filtration
  2. washwashed with diethyl ether
  3. customCrystallization of the crude material
  4. dissolutionby dissolving the powder in hot ethanol
  5. additionadding water
  6. filtrationfiltering the solution hot
  7. temperatureto cool
  8. filtrationFiltration
  9. customdrying of the solid
  10. customcollected

出典と根拠

ORDレコード
ord-7146eb8919b24b5283fe3bd2333e53fd
出典データセット
uspto-grants-1991_02
特許番号
US04994486

反応ノート

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