Phosphorus oxychloride → 2-Chloroimidazo[1,2-a]pyridine-3-sulfonyl chloride
反応式
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[S:11]([OH:14])(=O)=[O:12].P(Cl)(Cl)([Cl:17])=O>>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[S:11]([Cl:17])(=[O:14])=[O:12]参加物
3
実験手順
In 30 ml of phosphorus oxychloride is suspended 5.0 g of 2-chloroimidazo[1,2-a]pyridine-3-sulfonic acid and the suspension is refluxed for 5 hours. After cooling, the reaction mixture is poured in 250 ml of ice-water and extracted with dichloromethane. The dichloromethane layer is separated and dried over anhydrous sodium sulfate and the dichloromethane is distilled off under reduced pressure to give 4.6 g of the title compound as pale yellow crystals.
後処理
- temperaturethe suspension is refluxed for 5 hours
- temperatureAfter cooling
- extractionextracted with dichloromethane
- customThe dichloromethane layer is separated
- dry with materialdried over anhydrous sodium sulfate
- distillationthe dichloromethane is distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-b50b99e516b14d7c8132c1224a6d283f
- 出典データセット
- uspto-grants-1991_02
- 特許番号
- US04994571
反応ノート
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