化工社化工社 化学情報印刷レポート · 研究参考用
4,5-Difluorophthalic Anhydride → 3,4-Difluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,5-Difluorophthalic Anhydride | HCID 639745 | — |
| 反応物 | 4,5-Difluorophthalic Acid | HCID 643382 | — |
| 反応物 | 2-Amino-4,5-difluorobenzoic acid | HCID 735965 | — |
| 触媒 | Nickel | HCID 935 | — |
| 触媒 | Copper oxide | HCID 14829 | — |
| 触媒 | Copper | HCID 23978 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 触媒 | Dimethylacetamide | HCID 31374 | — |
| 触媒 | 4,5-Difluorophthalic Anhydride | HCID 639745 | — |
| 触媒 | 4,5-Difluorophthalic Acid | HCID 643382 | — |
| 溶媒 | Quinoline | HCID 7047 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 3,4-Difluorobenzoic acid | HCID 99166 | — |
反応手順
According to the present invention, 4,5-difluoroanthranilic acid may be prepared from either 4,5 difluorophthalic anhydride or 4,5-difluorophthalic acid. The process of this invention comprises the decarboxylation of either 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid in N-methyl-2-pyrrolidone, quinoline, or dimethyl acetamide solution optionally using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst, to yield 3,4-difluorobenzoic acid; the nitration of the 3,4-difluorobenzoic acid in a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid; and the reduction of the 2-nitro-4,5-difluorobenzoic acid to form 4,5-difluoroanthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04994606 |
| 出典データセット | uspto-grants-1991_02 |
| ORD ID | ord-abd76a9e685448ffbabde4fe3177bde7 |
| 出典メモ | uspto-grants-1991_02 |