Dimethylacetamide → Quinoline

HRID 982196

反応式

HRID 982196 の反応式
F[C:2]1[CH:3]=[C:4]2[C:9](=O)OC(=O)[C:5]2=[CH:11][C:12]=1F.[F:14][C:15]1[CH:16]=[C:17]([C:25]([OH:27])=[O:26])[C:18](=[CH:22][C:23]=1[F:24])C(O)=O.[CH3:28][C:29]([N:31](C)C)=O>CN1CCCC1=O>[N:31]1[C:5]2[C:4](=[CH:3][CH:2]=[CH:12][CH:11]=2)[CH:9]=[CH:28][CH:29]=1.[F:14][C:15]1[CH:16]=[C:17]([CH:18]=[CH:22][C:23]=1[F:24])[C:25]([OH:27])=[O:26]

参加物

6

反応物 3

HCID 31374DimethylacetamideHCID 6397454,5-Difluorophthalic AnhydrideHCID 6433824,5-Difluorophthalic Acid

生成物 2

HCID 7047QuinolineHCID 991663,4-Difluorobenzoic acid

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

Surprisingly, we have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be selectively decarboxylated in N-methyl-pyrrolidone, dimethyl acetamide or quinoline to yield 3,4-difluorobenzoic acid.

出典と根拠

ORDレコード
ord-d666b3202b4042d58b36b042b1da0a9d
出典データセット
uspto-grants-1991_02
特許番号
US04994606

関連ノート

読み込み中…