関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tridecane | HCID 12388 | — |
| 反応物 | 4,5-Difluorophthalic Acid | HCID 643382 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 3,4-Difluorobenzoic acid | HCID 99166 | 87% |
反応手順
4,5-difluorophthalic acid (0.55 grams, 2.7 mmole) was added to a slurry of cupric oxide (10% by weight of starting material) in 5 ml. of N-methyl-2-pyrrolidone solvent. n-tridecane (0.25 grams) was added as an internal standard. The mixture was heated to 190° C. for 3 hours, at which time GC analysis indicated complete consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield, based upon the internal standard, corrected for response factors.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04994606 |
|---|
| 出典データセット | uspto-grants-1991_02 |
|---|
| ORD ID | ord-59c929004c3e4d979a5fd179c9fad39c |
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| 出典メモ | uspto-grants-1991_02 |
|---|
