1,1-Dibromoethane → 1,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

HRID 982442ノート

反応式

HRID 982442 の反応式
[C:1]1(/[C:7](/[C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[C:8](/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)\[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:25][CH:26](Br)[CH3:27].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[C:1]1([C:7]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:27][CH2:26][Br:25])=[CH:22][CH:23]=2)=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 112011,1-DibromoethaneHCID 11430Potassium CarbonateHCID 13298065Z-4-(4-hydroxy-1,2-diphenyl-but-1-enyl)-phenol

生成物 1

HCID 544646161,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture containing 31.6 g of (Z)-1,2-diphenyl-1-(4-hydroxyphenyl)-1-buten-4-ol, 93.9 g of dibromoethane, 20.7 g of anhydrous potassium carbonate and 250 ml of methyl ethyl ketone is refluxed for 24 h. The inorganic salts are removed by filtration followed by evaporating the solvent and recrystallizing from methanol. The yield is 17.3 g (41%) and m.p. 133°-7° C.

後処理

  1. temperatureis refluxed for 24 h
  2. customThe inorganic salts are removed by filtration
  3. customby evaporating the solvent
  4. customrecrystallizing from methanol

出典と根拠

ORDレコード
ord-779fa5d296e14f008aece5d991d133c1
出典データセット
uspto-grants-1991_02
特許番号
US04996225

反応ノート

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