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Triethylamine → D-leucic acid 4-nitrobenzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 反応物 | (R)-2-hydroxy-4-methylpentanoic acid | HCID 439960 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | D-leucic acid 4-nitrobenzyl ester | HCID 86744637 | 98% |
反応手順
10.45 g of D-leucic acid was dissolved in 150 ml of ethyl acetate. 11 ml of triethylamine and 18.78 g of 4-nitrobenzyl bromide were added and the mixture was heated under reflux for 3 hours. The mixture was washed in sequence with water, 10% citric acid solution, saturated sodium hydrogen carbonate solution, water and saturated sodium chloride solution. After drying over anhydrous sodium sulfate and evaporation, there were obtained 20.6 g (98%) of D-leucic acid 4-nitrobenzyl ester as a gum. Rf (chloroform) 0.37.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04996358 |
| 出典データセット | uspto-grants-1991_02 |
| ORD ID | ord-09c4995c8d274c228b43eff3835e827b |
| 出典メモ | uspto-grants-1991_02 |