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3,4-Difluorobenzyl Chloride → 4-carboxy-2-(3,4-difluorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Difluorobenzyl Chloride | HCID 2736954 | — |
| 反応物 | 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991459 | — |
| 生成物 | 4-carboxy-2-(3,4-difluorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one | HCID 22562308 | 66.7% |
反応手順
Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3,4-difluorobenzyl chloride were reacted. Without purification, the reaction product was reacted further following the procedure of Example 1(7) to yield the title compound as a pale yellow solid (yield: 66.7%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06861428B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-6e924e461c0c4b41ac1a9932e726075d |
| 出典メモ | uspto-grants-2005_03 |