2,3-Dimethyl-6-methoxyindole → 2,3-Dimethyl-1H-indol-6-ol

HRID 982834ノート

反応式

HRID 982834 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH3:11])=[CH:8][CH:7]=[C:6]([O:12]C)[CH:5]=2.Cl.N1C=CC=CC=1>O>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH3:11])=[CH:8][CH:7]=[C:6]([OH:12])[CH:5]=2

参加物

4

反応物 2

HCID 2665942,3-Dimethyl-6-methoxyindoleHCID 10176127Pyridinium chloride

生成物 1

HCID 221414062,3-Dimethyl-1H-indol-6-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

2,3-Dimethyl-6-methoxy-1H-indole (2.0 g; synthesized by the process reported by Ockenden et al., J. Chem. Soc., pp. 3175-3180 (1957)) was mixed with pyridine hydrochloride (7.91 g; mfd. by KANTO KAGAKU). The resulting mixture was stirred at 200° C. for 15 minutes and then cooled. After adding water (100 mL), the mixture was then extracted with ethyl acetate (100 mL). The organic layer was dried over anhydrous sodium sulfate (10 g). The solvent was distilled off under reduced pressure to yield crude 2,3-dimethyl-6-hydroxy-1H-indole (1.86 g) as a gray crystal.

後処理

  1. customsynthesized by the process
  2. temperaturecooled
  3. extractionthe mixture was then extracted with ethyl acetate (100 mL)
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate (10 g)
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-adf8a250c7134758ae175e70bd31cc16
出典データセット
uspto-grants-2005_03
特許番号
US06861444B2

反応ノート

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