rel-(2R,6S)-2,6-dimethylpiperazine → 4-[(cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrole-2-carbaldehyde

反応式

[CH:1]([C:3]1[NH:7][CH:6]=[C:5]([C:8]([OH:10])=O)[C:4]=1[CH3:11])=[O:2].[CH3:12][C@H:13]1[CH2:18][NH:17][CH2:16][C@@H:15]([CH3:19])[NH:14]1>>[CH3:12][C@H:13]1[NH:14][C@@H:15]([CH3:19])[CH2:16][N:17]([C:8]([C:5]2[C:4]([CH3:11])=[C:3]([CH:1]=[O:2])[NH:7][CH:6]=2)=[O:10])[CH2:18]1

参加物

反応物 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazine

HCID 221354535-Formyl-4-methyl-1H-pyrrole-3-carboxylic acid

生成物 1

HCID 207615334-[(cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrole-2-carbaldehyde収率 88%

実験手順

5-Formyl-4-methyl-1H-pyrrole-3-carboxylic acid (1.00 g, 6.54 mmol) reacted with cis-2,6-dimethylpiperazine (822 mg, 7.19 mmol) to give 4-[(cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrole-2-carbaldehyde (1.43 g, 88%).

出典と根拠

ORDレコード: ord-e3bc3617befd44658d9eb07158118f4a
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06861418B2

反応ノート

読み込み中…