Potassium Hydroxide → 5-formyl-4-methyl-1H-pyrrole-2-carboxylic Acid
反応式
C([O:3][C:4]([C:6]1[NH:7][C:8]([CH:12]=[O:13])=[C:9]([CH3:11])[CH:10]=1)=[O:5])C.[OH-].[K+]>O.C(O)C>[CH:12]([C:8]1[NH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][C:9]=1[CH3:11])=[O:13]参加物
5
反応条件
- 温度
- 100 °C
実験手順
To a solution of 0.8 g (4.4 mmol) of 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester in 35 mL of water and 15 mL of ethanol was added 0.5 gram (8.9 mmol) of potassium hydroxide. The reaction mixture was heated to 100° C. for 1 h, cooled to room temperature, and evaporated ethanol. The water layer was acidified to pH=3 using 2N hydrogen chloride solution. The precipitate was filtered and washed with water to afford 0.67 g (68%) of 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid as a tan solid.
後処理
- temperaturecooled to room temperature
- customevaporated ethanol
- filtrationThe precipitate was filtered
- washwashed with water
出典と根拠
- ORDレコード
- ord-0b939ec4ac50443d850dc63039196c36
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06861418B2
反応ノート
読み込み中…