N,N-Diethylethylenediamine → 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide

反応式

[CH:1]([C:3]1[NH:4][C:5]([CH3:11])=[CH:6][C:7]=1[C:8]([OH:10])=O)=[O:2].[CH2:12]([N:14]([CH2:18][CH3:19])[CH2:15][CH2:16][NH2:17])[CH3:13]>>[CH2:12]([N:14]([CH2:18][CH3:19])[CH2:15][CH2:16][NH:17][C:8]([C:7]1[CH:6]=[C:5]([CH3:11])[NH:4][C:3]=1[CH:1]=[O:2])=[O:10])[CH3:13]

参加物

反応物 2

HCID 60993N,N-Diethylethylenediamine

HCID 219155882-formyl-5-methyl-1H-pyrrole-3-carboxylic acid

生成物 1

HCID 207617692-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide収率 94.4%

実験手順

2-Formyl-5-methyl-1H-pyrrole-3-carboxylic acid (3.0 g, 19.6 mmol) reacted with N,N-diethylethylenediamine (3.03 mL, 21.5 mmol) to give 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide (4.65 g, 94%).

出典と根拠

ORDレコード: ord-362caf655c594b128c616fb9d28c968f
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06861418B2

反応ノート

読み込み中…