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4-Phenylindolin-2-one → 3-[4-((cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrol-2-ylmethylene]-phenyl-1,3-dihydro-indol-2-one

HRID 983161
ノート
印刷プレビュー

反応式

HRID 983161 の反応式
C1([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)C=CC=CC=1.[CH3:17][C@H:18]1[NH:23][C@@H:22]([CH3:24])[CH2:21][N:20]([C:25]([C:27]2[C:28]([CH3:34])=[C:29]([CH:32]=O)[NH:30][CH:31]=2)=[O:26])[CH2:19]1>C(O)C.N1CCCCC1>[CH3:17][C@H:18]1[NH:23][C@@H:22]([CH3:24])[CH2:21][N:20]([C:25]([C:27]2[C:28]([CH3:34])=[C:29]([CH:32]=[C:13]3[CH:12]=[CH:8][CH:7]=[C:15]([N:11]4[C:12]5[C:8](=[CH:7][CH:15]=[CH:14][CH:13]=5)[CH2:9][C:10]4=[O:16])[CH2:14]3)[NH:30][CH:31]=2)=[O:26])[CH2:19]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 130486014-Phenylindolin-2-oneHCID 207615334-[(cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrole-2-carbaldehyde

生成物 1

HCID 697421343-[4-((cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrol-2-ylmethylene]-phenyl-1,3-dihydro-indol-2-one収率 38.9%

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 702
Ethanol
溶媒

実験手順

To a solution of 4-phenyl-1,3-dihydro-indol-2-one (52.3 mg, 0.25 mmol) and 4-[(cis)3,5-dimethyl-piperazine-carbonyl]-3-methyl-1H-pyrrole-2-carbaldehyde (64.8 mg, 0.26 mmol) in ethanol (2 mL) was added piperidine (3 drops). The reaction mixture was stirred at room temperature for three days. A yellow solid product was precipitated out, filtered, washed by ethanol for three times, and dried under high vacuum to provide pure product 3-[4-((cis)-3,5-dimethyl-piperazine-1-carbonyl]-3-methyl-1H-pyrrol-2-ylmethylene]-phenyl-1,3-dihydro-indol-2-one as a yellow solid (21.5 mg, 20%).

後処理

  1. customA yellow solid product was precipitated out
  2. filtrationfiltered
  3. washwashed by ethanol for three times
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-c899b15644474acfae3e1772ee6d8190
出典データセット
uspto-grants-2005_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06861418B2

反応ノート

読み込み中…

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