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HRID 983265作成日：2026年10月26日

Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl

https://huagongshe.com/reaction/983265

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物Diethyl acetamido[(pyridin-3-yl)methyl]propanedioateHCID 13817914—
生成物H-Ala(3-pyridyl)-OMe.2HClHCID 46862166100%

反応手順

Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06861558B2
出典データセットuspto-grants-2005_03
ORD IDord-7a1cad54d7c8448792ec806eaf3175c3
出典メモuspto-grants-2005_03