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Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate → Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate | HCID 4685119 | — |
| 反応物 | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate | HCID 10158832 | — |
反応手順
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (Aldrich), the title compound was prepared as a solid (mp=37-40° C.). The reaction was monitored by tlc (Rf=0.64 in 10% MeOH/DCM).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06861558B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-d0289fdfcf9f489e831ebd4f8259419d |
| 出典メモ | uspto-grants-2005_03 |