methyl (2S)-2-aminopentanoate hydrochloride → Methyl N-[N-(3-nitrophenylacetyl)-L-alaninyl]-(S)-2-aminopentanoate

HRID 983314ノート

反応式

HRID 983314 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C@H:14]([C:16]([OH:18])=O)[CH3:15])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[NH2:20][C@@H:21]([CH2:26][CH2:27][CH3:28])[C:22]([O:24][CH3:25])=[O:23]>C(Cl)(Cl)Cl.CO>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C@H:14]([C:16]([NH:20][C@@H:21]([CH2:26][CH2:27][CH3:28])[C:22]([O:24][CH3:25])=[O:23])=[O:18])[CH3:15])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 14118488methyl (2S)-2-aminopentanoate hydrochlorideHCID 53788870N-(3-Nitrophenylacetyl)-L-alanine

生成物 1

HCID 22894966Methyl N-[N-(3-nitrophenylacetyl)-L-alaninyl]-(S)-2-aminopentanoate

試薬・触媒・溶媒 1

HCID 21584188Chloroform methanol溶媒

実験手順

Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D11 above) and methyl (S)-2-aminopentanoate hydrochloride (prepared from (S)-2-aminopentanoic acid (Novabiochem) using General Procedure H), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.4 in 9:1 CHCl3/MeOH).

出典と根拠

ORDレコード
ord-f303063334d742a6b51a4edf5a9aa552
出典データセット
uspto-grants-2005_03
特許番号
US06861558B2

反応ノート

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