Potassium Carbonate → HCID 21362788、化合物

HRID 983462ノート

反応式

HRID 983462 の反応式
[CH:1]([NH:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH2:13][N:14]([CH2:32][CH3:33])[CH:15]2[CH2:24][CH2:23][C:22]3[C:17](=[CH:18][C:19]([NH:25]C(=O)C(F)(F)F)=[CH:20][CH:21]=3)[CH2:16]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:1]([NH:4][C:5]([N:7]1[CH2:8][CH2:9][CH:10]([CH2:13][N:14]([CH:15]2[CH2:24][CH2:23][C:22]3[C:17](=[CH:18][C:19]([NH2:25])=[CH:20][CH:21]=3)[CH2:16]2)[CH2:32][CH3:33])[CH2:11][CH2:12]1)=[O:6])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 86589089HCID 86589089、化合物

生成物 1

HCID 21362788HCID 21362788、化合物収率 95.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of the 4-({ethyl-[7-(2,2,2-trifluoro-acetylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amino}-methyl)-piperidine-1-carboxylic acid isopropylamide (630 mg, 1.3 mmol) in methanol (20 mL) and water (10 mL) was added potassium carbonate (500 mg) and the reaction was allowed to stir at room temperature for 24 h. The reaction was concentrated in vacuo and partitioned between EtOAc and water. The organic layer was washed with brine, dried (MgSO4) and concentrated to afford 4-{[(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-ethyl-amino]-methyl}-piperidine-1-carboxylic acid isopropylamide as a light brown oil (464 mg).

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. custompartitioned between EtOAc and water
  3. washThe organic layer was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-c0e679de8fe1416599f281c2d982de67
出典データセット
uspto-grants-2005_03
特許番号
US06864266B2

反応ノート

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