関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]- | HCID 11458991 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde | HCID 639857 | — |
反応手順
A 150 ml of NaOH-solution (5 M in water) is added to a solution of 59.2 g (252 mmol) of 17 in 200 ml of ethanol and the mixture is stirred overnight at 40° C. The reaction mixture is cooled in an ice bath and neutralized with HCl (5 M) and extracted with dichloromethane. The organic layer is washed with a saturated NaHCO3-solution, with brine and dried over MgSO4. The solvents are evaporated under reduced pressure. The product is isolated as an oil and used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06864347B2 |
|---|
| 出典データセット | uspto-grants-2005_03 |
|---|
| ORD ID | ord-067bfc77490a46de92e6cddc0813553f |
|---|
| 出典メモ | uspto-grants-2005_03 |
|---|
