Sodium hydride → 4-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium hydride	HCID 24758	—
反応物	2-Chloromethyl 2-(trimethylsilyl)ethyl ether	HCID 2724271	—
反応物	HCID 178418822	HCID 178418822	—
生成物	4-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole	HCID 22018576	67%

反応手順

Reaction of 4-phenylimidazole (400 mg, 2.78 mmol), NaH (60%, 108 mg, 2.70 mmol), and SEMCl (520 uL/2.94 mmol) followed by column chromatography on silica gel (hexane/EtOAC 1:1) gave the title compound (500 mg, 67%) as a yellow oil. 1H NMR (300 MHz, CDCl3) δ0.00 (s, 9H), 0.92 (t, 2H, J=9.0 Hz), 3.54 (t, 2H, J=9.0 Hz), 5.27 (s, 2H), 7.17 (s, 1H), 7.37-7.47 (m, 3H), 7.56 (d, 2H, J=9.0 Hz), 7.68 (s, 1H). ES-MS m/z 275 (M+H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06864265B2
出典データセット	uspto-grants-2005_03
ORD ID	ord-bf9b026c186f4885a36188a86ec84fe2
出典メモ	uspto-grants-2005_03