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Sodium hydride → 5-tert-butyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 5-tert-butyl-1H-imidazole | HCID 498436 | — |
| 反応物 | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| 生成物 | 5-tert-butyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole | HCID 22018569 | 57.6% |
反応手順
Reaction of 5-tert-butyl-1H-imidazole (423 mg, 3.41 mmol), NaH (60%, 132 mg, 3.31 mmol), and SEMCl (639 uL, 3.61 mmol) followed by column chromatography on silica gel (hexane/EtOAC 3:2) gave the title compound (500 mg, 57%) as a yellow oil. 1H NMR (300 MHz, CDCl3) δ major isomer: 0.00 (s, 9H), 0.89 (t, 2H, J=7.5 Hz), 1.29 (s, 9H), 3.47 (t, 2H, J=7.5 Hz), 5.19 (s, 2H), 6.73 (s, 1H), 7.50 (s, 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06864265B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-0a0e3ab9f473443fad7ae8fa40b424dd |
| 出典メモ | uspto-grants-2005_03 |