Methanol → Methyl 6,8-dichlorooctanoate
反応式
[Cl:1][CH:2]([CH2:10][CH2:11][Cl:12])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].[CH3:13]O>Cl>[Cl:1][CH:2]([CH2:10][CH2:11][Cl:12])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:13])=[O:8]参加物
4
実験手順
9 g (0.042 moles) of (+)-6,8-dichlorooctanoic acid are dissolved in 120 ml of methanol containing 0.45 ml of aqueous hydrochloric acid at 37% by weight. The solution is refluxed for two hours, the solvent is evaporated at reduced pressure, 17 ml of toluene are added and the obtained solution is washed twice with 10 ml of water. The toluene phase is concentrated under vacuum, thus obtaining 9.4 g of methyl (+)-6,8-dichlorooctanoate (yield=98.6%).
後処理
- temperatureThe solution is refluxed for two hours
- customthe solvent is evaporated at reduced pressure, 17 ml of toluene
- additionare added
- washthe obtained solution is washed twice with 10 ml of water
- concentrationThe toluene phase is concentrated under vacuum
出典と根拠
- ORDレコード
- ord-0e53d33d585d42df9024bba873868f79
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06864374B2
反応ノート
読み込み中…