Hydrochloric Acid → n-(3-Acetylphenyl)-n'-((3s,4s)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanyl)urea hydrochloride

HRID 983678ノート

反応式

HRID 983678 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]([NH:13][C@H:14]2[C@H:18]([NH:19][CH:20]3[CH2:25][CH2:24][CH:23]([CH2:26][C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=4)[CH2:22][CH2:21]3)[CH2:17][O:16][CH2:15]2)=[O:12])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[ClH:34].CCOCC>ClCCl>[ClH:34].[C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]([NH:13][C@H:14]2[C@H:18]([NH:19][CH:20]3[CH2:21][CH2:22][CH:23]([CH2:26][C:27]4[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=4)[CH2:24][CH2:25]3)[CH2:17][O:16][CH2:15]2)=[O:12])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9911755n-(3-Acetylphenyl)-n'-((3s,4s)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanyl)urea

生成物 1

HCID 69588053n-(3-Acetylphenyl)-n'-((3s,4s)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanyl)urea hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirring solution of N-(3-acetylphenyl)-N′-((3S,4S)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanyl)urea (14 mg, 0.030 mmol) in dichloromethane (1 mL) was added 1.0 M hydrogen chloride in ether (300 μL, 0.030 mmol). After 5 min, the resulting solution was concentrated and the residue lyopholized to afford the desired hydrochloride (15 mg, 1000) as a white solid. MS (ESI) 454 (M−Cl)

後処理

  1. concentrationthe resulting solution was concentrated

出典と根拠

ORDレコード
ord-a0a4eaacf7744eb98554f3ee14eb6a7b
出典データセット
uspto-grants-2005_03
特許番号
US06864380B2

反応ノート

読み込み中…