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Diethyl Ether → 2,4-Dichlorobenzylidenemalononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Malononitrile | HCID 8010 | — |
| 反応物 | 2,4-Dichlorobenzaldehyde | HCID 13404 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2,4-Dichlorobenzylidenemalononitrile | HCID 18089 | — |
反応手順
Under an atmosphere of argon, 2,4-dichlorobenzaldehyde (30.00 g, 171 mmol) and malononitrile (13.59 g, 206 mmol) were suspended in 1-butanol (350 ml). After stirring for 15 min, 8 drops of piperidine were added at room temperature. After stirring for an additional 3 h, diethyl ether was added. The precipitate was filtered and washed with diethyl ether and hexane to give the title compound, MS: m/e=222.8 (M+), as a colorless solid (35.34 g, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06867205B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-5500adcfe11f4975895e20aa0422a449 |
| 出典メモ | uspto-grants-2005_03 |