Potassium Hydroxide → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

HRID 984154ノート

反応式

HRID 984154 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([O:18]CC)=[O:17])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-].[K+]>C(O)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([OH:18])=[O:17])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 16125879Ethyl 2-(3,4,5-trimethoxyphenyl)pyridine-4-carboxylate

生成物 1

HCID 120434852-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 2-(3,4,5-trimethoxyphenyl)isonicotinate (3.17 g) in ethanol (40 mL) was added 10% potassium hydroxide (2.42 g). The mixture was stirred at room temperature for 5 hours and evaporated. Water was added to the residue and pH was adjusted to 7. White precipitates of the title compound were collected by filtration and the compound was used for next step without further purification.

後処理

  1. customevaporated
  2. additionWater was added to the residue and pH
  3. customWhite precipitates of the title compound
  4. filtrationwere collected by filtration
  5. customthe compound was used for next step without further purification

出典と根拠

ORDレコード
ord-afb2fecf8cf54e918a70abdb439f87b3
出典データセット
uspto-grants-2005_03
特許番号
US06867221B2

反応ノート

読み込み中…