Diisobutylaluminum hydride → (E)-3-(3',5'-dibromo-biphenyl-4-yl)-but-2-en-1-ol

反応式

CC(C[AlH]CC(C)C)C.[Br:10][C:11]1[CH:12]=[C:13]([C:18]2[CH:23]=[CH:22][C:21](/[C:24](/[CH3:31])=[CH:25]/[C:26](OCC)=[O:27])=[CH:20][CH:19]=2)[CH:14]=[C:15]([Br:17])[CH:16]=1>>[Br:10][C:11]1[CH:12]=[C:13]([C:18]2[CH:19]=[CH:20][C:21](/[C:24](/[CH3:31])=[CH:25]/[CH2:26][OH:27])=[CH:22][CH:23]=2)[CH:14]=[C:15]([Br:17])[CH:16]=1

参加物

反応物 2

HCID 14487Diisobutylaluminum hydride

HCID 22557684(E)-ethyl 3-(3',5'-dibromo-biphenyl-4-yl)-but-2-enoate

生成物 1

HCID 69800831(E)-3-(3',5'-dibromo-biphenyl-4-yl)-but-2-en-1-ol

実験手順

The colourless gum (E)-3-(3′,5′-dibromo-biphenyl-4-yl)-but-2-en-1-ol was prepared by DIBAL-H reduction of (E)-ethyl 3-(3′,5′-dibromo-biphenyl-4-yl)-but-2-enoate as described for example 52b, with the purification of the product being carried out by preparative HPLC.

後処理

customas described for example 52b, with the purification of the product

出典と根拠

ORDレコード: ord-c97852fed5574e44aacc82274aa31b92
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06867218B2

反応ノート

読み込み中…

参加物