2,5-Dibromopyridine → HCID 22508330、化合物

HRID 984755

反応式

HRID 984755 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][N:11]=1.BrC1C=CC(Br)=CN=1.O1C2C=CC=CC=2C=C1B(O)O.[C:37]1(B(O)O)[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=[CH:39][CH:38]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([C:45]2[C:46]3[C:41](=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:42]=[CH:43][CH:44]=2)=[CH:12][N:11]=1

参加物

5

反応物 4

HCID 693532,5-DibromopyridineHCID 2545321-Naphthaleneboronic acidHCID 2776266Benzo[b]furan-2-boronic acidHCID 225083352-(Benzofuran-2-yl)-5-bromopyridine

生成物 1

HCID 22508330HCID 22508330、化合物

実験手順

It is easy to synthesis the following compound in the same manner as in Example 1 except that 2-(benzofuran-2-yl)-5-bromopyridine was synthesized from 2,5-dibromopyridine (made by Tokyo Kasei Kogyo K.K.) and 2-benzofuranboronic acid (made by Aldrich Co.) and is reacted with 1-naphthylboronic acid (made by Tokyo Kasei Kogyo) to obtain 2-(benzofuran-2-yl)-5-(naphthalene-1-yl)pyridine, which is used instead of 2-(5-trifluoromethylpyridine-2-yl)benzofuran.

出典と根拠

ORDレコード
ord-2f166a52b26843e580feb808a15f8431
出典データセット
uspto-grants-2005_03
特許番号
US06869694B2

関連ノート

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