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2,5-Dibromopyridine → 2-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dibromopyridine | HCID 69353 | — |
| 反応物 | Thiophene-3-boronic acid | HCID 581760 | — |
| 反応物 | Benzo[b]furan-2-boronic acid | HCID 2776266 | — |
| 反応物 | 2-(Benzofuran-2-yl)-5-bromopyridine | HCID 22508335 | — |
| 生成物 | 2-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine | HCID 22508334 | — |
反応手順
It is easy to synthesis the following compound in the same manner as in Example 1 except that 2-(benzofuran-2-yl)-5-bromopyridine was synthesized from 2,5-dibromopyridine (made by Tokyo Kasei Kogyo K.K.) and 2-benzofuranboronic acid (made by Aldrich Co.) and is reacted with 3-thiopheneboronic acid (made by Aldrich Co.) to obtain 2-(benzofuran-2-yl)-5-(thiophene-3-yl)pyridine, which is used instead of 2-(5-trifluoromethylpyridine-2-yl)benzofuran.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06869694B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-c81d8596b33545ada16eb903414ed77a |
| 出典メモ | uspto-grants-2005_03 |