化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → 3,4-Dihydroxythiophene-2,5-dicarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3,4-Dihydroxy-thiophene-2,5-dicarboxylic acid diethyl ester | HCID 245503 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3,4-Dihydroxythiophene-2,5-dicarboxylic acid | HCID 316269 | — |
反応手順
EtOH (30 mL) was added to 2,5-dicarbethoxy-3,4-dihydroxythiophene (1 g). A solution of NaOH (4.0 g) in H2O (20 mL) was added and refluxed under N for 20 h. Upon cooling to ambient temperature the EtOH was removed by distillation and the residue was redissolved in H2O then acidified with 15% HClaq when a white ppt was obtained This product was collected by filtration and washed with cold H2O then crystallized from dilute MeOH to give colorless needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06869729B1 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-0e1c8a71196d4753a61e5b592f8c8adb |
| 出典メモ | uspto-grants-2005_03 |