化工社化工社 化学情報印刷レポート · 研究参考用
Imidazole → 1H-Imidazol-1-ylphenylmethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Bifonazole | HCID 2378 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 生成物 | 1H-Imidazol-1-ylphenylmethanone | HCID 66319 | 74.7% |
反応手順
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06870057B1 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-1b8366f4615041a388dd5cce112ded97 |
| 出典メモ | uspto-grants-2005_03 |