Ethyl Acetoacetate → 3-Allyl-6-methyluracil

HRID 985463

反応式

HRID 985463 の反応式
[CH2:1]([NH:4][C:5]([NH2:7])=[O:6])[CH:2]=[CH2:3].[C:8](OCC)(=[O:13])[CH2:9][C:10]([CH3:12])=O.[OH-].[K+]>C(O)C.Cl.CO>[CH2:1]([N:4]1[C:8](=[O:13])[CH:9]=[C:10]([CH3:12])[NH:7][C:5]1=[O:6])[CH:2]=[CH2:3]

参加物

7

反応物 3

HCID 8868Ethyl AcetoacetateHCID 11181AllylureaHCID 14797Potassium Hydroxide

生成物 1

HCID 136020473-Allyl-6-methyluracil

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

To allylurea (25 g, 25 mol) in ethanol (10 mL) was added ethyl acetoacetate (31.86 mL, 25 mol) and 10 drops conc. HCl. After 12 days at room temperature, concentration gave an oil which was dissolved in MeOH. KOH (22.5 g, 0.34 mol) was added and the solution refluxed for 1 hour. After neutralization, the resulting solid 1 was collected. Yield 2.7 g (7%). NMR (CDCl3) δ: 2.16 (3H, s), 4.52 (2H, d), 5.18 (1H, d), 5.23 (1H, d), 5.60 (1H, s), 5.82-5.93 (1H, m), 10.3 (1H, s).

後処理

  1. concentrationconcentration
  2. customgave an oil which
  3. temperaturethe solution refluxed for 1 hour
  4. customAfter neutralization, the resulting solid 1 was collected

出典と根拠

ORDレコード
ord-37a753e57f2a4877acb3d87e58643f7f
出典データセット
uspto-grants-2005_03
特許番号
US06872728B2

関連ノート

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