Sodium Dithionite → HCID 22506839、化合物

HRID 985572ノート

反応式

HRID 985572 の反応式
[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4]([C:5]([CH3:13])=[CH:6][C:7](=[O:12])[C:8]=2[CH3:11])=[N:3]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(OCC)(=O)C.O>[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4](=[C:5]([CH3:13])[CH:6]=[C:7]([OH:12])[C:8]=2[CH3:11])[NH:3]1

参加物

5

反応物 2

HCID 24489Sodium DithioniteHCID 22506843HCID 22506843、化合物

生成物 1

HCID 22506839HCID 22506839、化合物収率 83%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2,3-dihydro-2,2,4,7-tetramethyl-5H-indol-5-one (7.36 g, 38.9 mmol) in ethyl acetate (100 ml) was added a solution of sodium hydrosulfite (14.9 g, 85.6 mmol) in water (50 ml) and shaken. The aqueous layer was separated, and the organic layer was washed with water and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from ethanol-hexane to obtain 6.17 g of the title compound.

後処理

  1. customThe aqueous layer was separated
  2. washthe organic layer was washed with water and saturated brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from ethanol-hexane

出典と根拠

ORDレコード
ord-a3b42db1da98424989d852b792cf547c
出典データセット
uspto-grants-2005_03
特許番号
US06872718B1

反応ノート

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