Hydrochloric Acid → HCID 22507783、化合物

反応式

COCCOC[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]([S:22]([CH3:25])(=[O:24])=[O:23])[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:9][CH:8]=1.Cl.C[OH:28]>>[OH:28][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]([S:22]([CH3:25])(=[O:24])=[O:23])[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:9][CH:8]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 68901562HCID 68901562、化合物

生成物 1

HCID 22507783HCID 22507783、化合物

実験手順

A solution of the product of Step D (1.5 g, 4.0 mmol) in methanol (10 mL) was treated with HCl (10 mL, 4 N in dioxane). The reaction was allowed to stir for 2 hr, concentrated, and purified by silica gel chromatography (methanol:dichloromethane), to afford the title compound (0.93 g).

後処理

concentrationconcentrated
custompurified by silica gel chromatography (methanol:dichloromethane)

出典と根拠

ORDレコード: ord-82f05794caf94f94b1e4a59dd4a7b25a
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06872834B2

反応ノート

読み込み中…