Sodium Methoxide → 6-Bromo-3-cyano-2-methoxyquinoline
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([C:13]#[N:14])=[CH:5]2.[CH3:15][O-:16].[Na+]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:16][CH3:15])[C:6]([C:13]#[N:14])=[CH:5]2参加物
4
実験手順
A solution of 6-bromo-2-chloro-3-cyano-quinoline (1.2 g) in methanol (30 cm3) was heated under reflux for 16 hours with sodium methoxide [made from sodium (0.116 g) and methanol (20 cm3)]. The mixture was cooled to 0° and the solid filtered to afford 6-bromo-3-cyano-2-methoxyquinoline, m.p. 172°-174°, (0.60 g).
後処理
- temperatureThe mixture was cooled to 0°
- filtrationthe solid filtered
出典と根拠
- ORDレコード
- ord-10b48fe34e5946eeb3588d7bfce1a5e7
- 出典データセット
- uspto-grants-1987_12
- 特許番号
- US04710507
反応ノート
読み込み中…