Acetic Acid → Isopropyl 2-phenyl-4-quinolone-6-carboxylate

HRID 986239

反応式

HRID 986239 の反応式
N[C@H:2]([CH:7]=O)[CH2:3]CSC.[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([OH:28])=[O:27])[CH:21]=3)[N:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(O)(=O)C>C(O)(C)C>[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([O:28][CH:2]([CH3:7])[CH3:3])=[O:27])[CH:21]=3)[N:16]=2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 446793Methionin ALHCID 704325112-Phenyl-4-quinolone-6-carboxylic acid

生成物 1

HCID 70432651Isopropyl 2-phenyl-4-quinolone-6-carboxylate収率 78.8%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Metal sodium (0.33 gram) is dissolved in 40 ml of anhydrous isopropyl alcohol and the solution is heated to reflux for one hour with 2 grams of the 2-phenyl-4-quinolone-6-carboxylic acid obtained in Example 2. After cooling, the solution is mixed with ice water, acidified with acetic acid, the crystals which separate out therefrom are collected by filtration. The crystals are washed with water, washed with methanol, and dried to give 0.6 gram of isopropyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting at above 300° C.

後処理

  1. temperaturethe solution is heated
  2. temperatureAfter cooling
  3. customthe crystals which separate out
  4. filtrationtherefrom are collected by filtration
  5. washThe crystals are washed with water
  6. washwashed with methanol
  7. customdried

出典と根拠

ORDレコード
ord-ec7b457643e94d7f8fa23723661d1b4e
出典データセット
uspto-grants-1987_12
特許番号
US04711898

関連ノート

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