3,4-Dichloroaniline → 2-Chloro-N-[(3,4-dichlorophenyl)carbamoyl]-4-fluorobenzamide

HRID 986264ノート

反応式

HRID 986264 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[Cl:10][C:11]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:12]=1[C:13]([N:15]=[C:16]=[O:17])=[O:14]>C1(C)C=CC=CC=1>[Cl:10][C:11]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:12]=1[C:13]([NH:15][C:16]([NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)=[O:17])=[O:14]

参加物

4

反応物 2

HCID 72573,4-DichloroanilineHCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-

生成物 1

HCID 132368042-Chloro-N-[(3,4-dichlorophenyl)carbamoyl]-4-fluorobenzamide収率 94%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

3.24 g (0.02 mol) of 3,4-dichloroaniline are dissolved in 60 ml of dry toluene, and 3.99 g (0.02 mol) of 2-chloro-4-fluoro-benzoyl isocyanate are added in the absence of moisture. The mixture is stirred for one hour at 80° C. and then cooled to 20°-25° C. The precipitate which separates out is filtered off under suction and dried in vacuo at 100° C. 6.8 g (94% of theory) of 1-(2-chloro-4-fluoro-benzoyl)-3-(3,4-dichlorophenyl)-urea of melting point 208° C. are obtained.

後処理

  1. temperaturecooled to 20°-25° C
  2. filtrationThe precipitate which separates out is filtered off under suction
  3. customdried in vacuo at 100° C

出典と根拠

ORDレコード
ord-38549dc34926424faeddb41ba732d3f2
出典データセット
uspto-grants-1987_12
特許番号
US04711905

反応ノート

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