Dichloromethane → Ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate

HRID 986565ノート

反応式

HRID 986565 の反応式
[CH3:1][NH:2][C:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[CH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:16]=[C:17]1O[C:19](=[O:20])[CH2:18]1.C(Cl)Cl>CCOCC>[CH3:1][N:2]1[C:17]([CH3:16])=[CH:18][C:19](=[O:20])[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[C:3]1[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 12661DiketeneHCID 58005139Ethyl 3-(methylamino)-3-phenylacrylate

生成物 1

HCID 14075276Ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

10.25 g of ethyl beta-methylaminocinnamate, 9.4 g of technical grade diketene and 25 ml dry methylene chloride are mixed in a flask fitted with a calcium chloride drying tube. The reaction mixture is stored at room temperature for 117 hours. Approximately 75 ml of dry ether is added and the resulting crystalline solid is filtered to yield 8.5 g of ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate. mp (toluene)=244°-248° C.

後処理

  1. customfitted with a calcium chloride drying tube
  2. filtrationthe resulting crystalline solid is filtered

出典と根拠

ORDレコード
ord-4c7d3e8b011a413ea63b1f62ce7b3992
出典データセット
uspto-grants-1987_12
特許番号
US04714492

反応ノート

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