Sulfuryl chloride → 6-Amino-5,7-Dichloro-2-Methylbenzoxazole

HRID 9866

反応式

HRID 9866 の反応式
[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1.S(Cl)([Cl:16])(=O)=O>C(OCC)(=O)C>[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[C:3]=1[Cl:16]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 112754042-Methyl-5-chloro-6-benzoxazolamine

生成物 1

HCID 219887696-Amino-5,7-Dichloro-2-Methylbenzoxazole

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

後処理

  1. additionwas added
  2. filtrationAfter 1 hour the precipitate was filtered off
  3. washwashed with ether
  4. customair-dried

出典と根拠

ORDレコード
ord-e1a8a1d4fea343c68da40b757c689dec
出典データセット
uspto-grants-2006_08
特許番号
US07091361B2

関連ノート

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