Chloroacetic Acid → Benzimidazole, 2-chloromethyl-5,6-dichloro-

HRID 986664

反応式

HRID 986664 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.[Cl:11][CH2:12][C:13](O)=O>Cl>[Cl:11][CH2:12][C:13]1[NH:10][C:4]2[CH:3]=[C:2]([Cl:1])[C:7]([Cl:8])=[CH:6][C:5]=2[N:9]=1

参加物

4

反応物 2

HCID 300Chloroacetic AcidHCID 792974,5-Dichloro-1,2-phenylenediamine

生成物 1

HCID 38349Benzimidazole, 2-chloromethyl-5,6-dichloro-収率 80.7%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 1.77 g (10 m mol) of 4,5-dichloro-1,2-phenylenediamine in 15 ml of 4N aqueous hydrochloric acid was stored at room temperature overnight. To the solution was added 1.42 g (15 m mol) of monochloroacetic acid, and refluxed for 3 hours and filtered. The filterate was cooled to room temperature, stirred and rendered alkaline by addition of ammonium hydroxide. The separated precipitate was washed with water and dried to give 1.9 g (68%) of the title compound.

後処理

  1. temperaturerefluxed for 3 hours
  2. filtrationfiltered
  3. additionby addition of ammonium hydroxide
  4. washThe separated precipitate was washed with water
  5. customdried

出典と根拠

ORDレコード
ord-6f3ea686ca0c44848b783cb11ef233c2
出典データセット
uspto-grants-1987_12
特許番号
US04714764

関連ノート

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