関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Malonic Acid | HCID 867 | — |
| 反応物 | N,N'-Bis(1-methylethyl)urea | HCID 20084 | — |
| 反応物 | 1,3-diisopropylpyrimidine-2,4,6(1H,3H,5H)-trione | HCID 4182618 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | Cyclohexane | HCID 8078 | 70% |
| 生成物 | 1,3-diisopropylpyrimidine-2,4,6(1H,3H,5H)-trione | HCID 4182618 | — |
反応手順
1,3-Diisopropyl-2,4,6-(1H,3H,5H)-pyrimidinetrione was prepared by the dropwise addition of acetic anhydride (40 ml) over three hours to a solution of 1,3-diisopropylurea (7.5 g, 0.05 mole) and malonic acid (5.2 g, 0.05 mole) at 65° C. After the addition was completed, the temperature was raised to 90° C. and maintained for three hours. The solvent was evaporated under reduced pressure and the residue solidified upon cooling. 1,3-Diisopropyl-2,4,6-(1H,3H,5H)-pyrimidinetrione recrystallized from cyclohexane as colorless needles (7.3 g, 70% yield), m.p. 79°-82°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04714838 |
|---|
| 出典データセット | uspto-grants-1987_12 |
|---|
| ORD ID | ord-82c7cdc88ad7479681c6097013818b74 |
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| 出典メモ | uspto-grants-1987_12 |
|---|
