Methyl Isocyanate → alpha-[1-Methyl-imidazolin-2-yl]-alpha-(O-methylaminocarbonyloximino)-acetonitrile

HRID 986718ノート

反応式

HRID 986718 の反応式
[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[C:7](=[N:10][OH:11])[C:8]#[N:9].[CH3:12][N:13]=[C:14]=[O:15]>C(OCC)(=O)C.C(N(CC)CC)C>[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[C:7](=[N:10][O:11][C:14]([NH:13][CH3:12])=[O:15])[C:8]#[N:9]

参加物

5

反応物 2

HCID 12228Methyl IsocyanateHCID 136408868HCID 136408868、化合物

生成物 1

HCID 54502986alpha-[1-Methyl-imidazolin-2-yl]-alpha-(O-methylaminocarbonyloximino)-acetonitrile

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 8857Ethyl Acetate溶媒

実験手順

15.2 g (0.1 mol) of α-[1-methyl-imidazolin-2-yl]-α-oximino-acetonitrile and 6.4 g (0.11 mol) of methyl isocyanate are stirred in 200 ml of ethyl acetate with a few drops of triethylamine for 16 hours. 16 g (76.5% of theory) of end product are filtered off and this is washed with a little ethyl acetate; melting point 186°-190° C. (decomposition).

後処理

  1. filtration16 g (76.5% of theory) of end product are filtered off
  2. washthis is washed with a little ethyl acetate

出典と根拠

ORDレコード
ord-3b4b62404f5f4341b1b713292e908d99
出典データセット
uspto-grants-1987_12
特許番号
US04715883

反応ノート

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