関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Resazurin | HCID 11077 | — |
| 反応物 | HCID 178427469 | HCID 178427469 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 178427470 | HCID 178427470 | — |
反応手順
1 mmol of Tos-Gly-Pro-Arg-OH was suspended in 30 ml of tetrahydrofuran (dry). 4 mmol of ethyl chloroformate were added at room temperature, and the mixture was stirred for about 15 minutes and cooled to -10° C. 3 mmol of N-methylmorpholine were added and the mixture was stirred at room temperature for 60 minutes. 3 mmol of resazurin in 60 ml of desiccated tetrahydrofuran were then admixed dropwise. The reaction was complete after 4 h and the mixture was filtered and the filtrate was evaporated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04716222 |
|---|
| 出典データセット | uspto-grants-1987_12 |
|---|
| ORD ID | ord-f09c513ba5ea4ca4a981bb3e3a3ec2f8 |
|---|
| 出典メモ | uspto-grants-1987_12 |
|---|
