Diethyl Ether → HCID 178463964、化合物

HRID 986849

反応式

HRID 986849 の反応式
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:3].[H][H].CCOCC>Cl>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C@H:10]1[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11]1)([CH3:9])[CH3:8])[CH3:3]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 201566692-Amino-6-(4-aminophenyl)-6-methylheptaneHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 178463964HCID 178463964、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

5.0 Parts of 2-amino-6-(4-aminophenyl)-6-methylheptane dissolved in 68 parts of 1N aqueous hydrochloric acid were shaken at room temperature and atmospheric pressure with hydrogen in the presence of 0.5 parts of Nishimura catalyst (rhodium-platinum oxides). Hydrogen uptake ceased at 105% of theory and the solution was filtered free of catalyst and treated with sodium hydroxide solution to give an oil which was isolated with ether. After removing the ether the residue was distilled to give 4.0 parts of cis and trans-2-amino-6-(4-aminocyclohexyl)-6-methyl-heptane b0.3 120°-9° with the following percentage composition by weight.

後処理

  1. filtrationthe solution was filtered free of catalyst
  2. additiontreated with sodium hydroxide solution
  3. customto give an oil which
  4. customAfter removing the ether the residue
  5. distillationwas distilled

出典と根拠

ORDレコード
ord-bbbe8691bcf548d4a8c7dcad54652f95
出典データセット
uspto-grants-1987_12
特許番号
US04716248

関連ノート

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