HCID 53643183、化合物 → HCID 22988045、化合物
反応式
[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1)[CH2:5][NH:6]C(OC(C)(C)C)=O>Cl.O1CCOCC1>[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:14][C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1)[CH2:5][NH2:6]参加物
3
実験手順
A solution of 3-tert-butoxycarbonylamino-2-(pyrimidin-2-ylamino)-propionic acid methyl ester (227 mg, 0.77 mmol) in HCl/dioxane (4 N, 5 mL) was stirred at room temperature for 1 hour. The solution was then concentrated to dryness and the residue was dissolved in water (20 mL). This solution was then washed with dichloromethane (2×10 mL) and hexanes (10 mL). The solution was then filtered and lyophilized to yield (+/−)-3-amino-2-(pyrimidin-2-ylamino)-propionic acid methyl ester as a yellow solid (185 mg, 90%).
後処理
- concentrationThe solution was then concentrated to dryness
- dissolutionthe residue was dissolved in water (20 mL)
- washThis solution was then washed with dichloromethane (2×10 mL) and hexanes (10 mL)
- filtrationThe solution was then filtered
出典と根拠
- ORDレコード
- ord-288349d5ca4c45da97e8b640fa73a6c3
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06630488B1
反応ノート
読み込み中…