Water → 2-Ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester

HRID 987266ノート

反応式

HRID 987266 の反応式
[CH3:1][O:2][C:3](=[O:26])[CH:4]([O:23][CH2:24][CH3:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[CH:8][C:7]=1[N+:20]([O-:22])=[O:21].CSC.B(F)(F)F.CCOCC.O>ClCCl>[CH3:1][O:2][C:3](=[O:26])[CH:4]([O:23][CH2:24][CH3:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[N+:20]([O-:22])=[O:21]

参加物

6

反応物 4

HCID 962WaterHCID 1068Dimethyl SulfideHCID 8000Boron trifluoride etherateHCID 538566552-Ethoxy-3-(4-benzyloxy-2-nitrophenyl)propanoic acid methyl ester

生成物 1

HCID 538988402-Ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester収率 95.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2-Ethoxy-3-(4-benzyloxy-2-nitrophenyl)propanoic acid methyl ester (1.5 g; 4.06 mmole) was dissolved in dichloromethane (8 ml) and dimethylsulfide (8 ml) was added. Boron trifluoride diethyl etherate (5.0 ml; 40.6 mmole) was added under stirring. The reaction mixture was stirred at room temperature for 4 hours and then poured into water and more dichloromethane was added. The phases were separated and the organic phase was washed with water and brine and dried with magnesium sulfate. Evaporation to remove the solvent gave 1.04 g (95% yield) of 2-ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester.

後処理

  1. stirringThe reaction mixture was stirred at room temperature for 4 hours
  2. additionwas added
  3. customThe phases were separated
  4. washthe organic phase was washed with water and brine
  5. dry with materialdried with magnesium sulfate
  6. customEvaporation
  7. customto remove the solvent

出典と根拠

ORDレコード
ord-61bb798f6fec47ba9c11000f3914bff2
出典データセット
uspto-grants-2003_10
特許番号
US06630600B1

反応ノート

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