化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one | HCID 4293995 | — |
| 反応物 | (R)-1-Benzoyl-3-methylpiperazine | HCID 7578227 | — |
| 反応物 | Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt | HCID 23721194 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)- | HCID 5495793 | — |
反応手順
Potassium 7-azaindole 3-glyoxylate 3a (25.4 g, 0.111 mol), (R)-3-methyl-N-benzoylpiperazine 4a (22.7 g, 0.111 mol), 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) (33.3 g, 0.111 mol) and Hunig's Base (28.6 g, 0.222 mol) were combined in 500 ml of DMF. The mixture was stirred at room temperature for 8 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06632819B1 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-b851d8dd80544e44a023f938ddc10fee |
| 出典メモ | uspto-grants-2003_10 |